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Research

Running Projects

Running Projects

 

Magneto-mechanical study of cell growth and proliferation in micro-pores (project description)
PI: John Dunlop (MPIKG)
Collaboration: Damien Faivre, Stefan Klumpp (MPIKG)

Vibrational spectroscopy of light-activated membrane proteins (project description)
PI: Joachim Heberle (FU)
Collaboration: Rumiana Dimova (MPIKG)

Carbohydrate binding proteins and their impact on host/pathogen interaction (project description)
PI: Bernd Lepenies (U Hannover), Thomas Meyers (MPI-IB)
Collaboration: Stefanie Barbirz (UP), Mark Santer (MPIKG)

Biochemical approach to study biomaterials: link between protein matrix nature to mechanical properties in spider cuticles (project description)
PI: Yael Politi / Peter Fratzl (MPIKG)
Collaboration: Friedrich Barth, Elena Degtyar (MPIKG)

Elucidating the thermal isomerization of azobenzene (project description)
PI: Mark Santer (MPIKG)
Collaboration: Peter Saalfrank (UP)

Juggling with flexible biomolecules (project description)
PI: Daniel Varon-Silva (MPIKG)
Collaboration: Mark Santer, Christoph Rademacher (MPIKG)

Optically controlled shape of soft nano-objects (project description)
PI: Svetlana Santer (UP)
Collaboration: Mark Santer (MPIKG)

Axonal transport of Neurexin vesicles by teams of molecular motors (project description)
PI: Stephan Sigrist (FU)
Collaboration: Reinhard Lipowsky (MPIKG)

Assembled Nanomagnets: Ferromagnetic Resonance Spectroscopy of Magnetotactic Bacteria (project description)
PI: Damien Faivre (MPIKG)
Collaboration: Peter Strauch, Stefan Klumpp (MPIKG)

The role of sulfur-transferring proteins associated with the centrosome (project description)
PI: Ralph Gräf (UP)
Collaboration: Silke Leimkühler (UP)

Investigating the role of fluorinated amino acids on protein structure and function using simulation (project description)
PI: Ana Vila Verde (MPIKG)
Collaboration: Beate Koksch (FU)

Molecular force sensors for the extracellular matrix (project description)
PI: Kerstin Blank (MPIKG)
Collaboration: John Dunlop (MPIKG)

Size control during eukaryotic cell division (project description)
PI: Carsten Beta (UP)
Collaboration: Angelo Valleriani (MPIKG)

Probing collagen nanomechanics (project description)
PI: Luca Bertinetti, Kerstin Blank (MPIKG)
Collaboration: Admir Masic, Emanuel Schneck (MPIKG)

Coiled coils as mechanical building blocks (project description)
PI: Kerstin Blank (MPIKG)
Collaboration: Beate Koksch (FU)

Growing elongated: How magnetotactic bacteria synthesize anisotropic magnetite (project description)
PI: Damien Faivre (MPIKG)
Collaboration: Kerstin Blank (MPIKG)

Computational design of magnetic microswimmers: Understanding the relation of shape and speed (project description)
PI: Damien Faivre (MPIKG)
Collaboration: Stefan Klumpp (MPIKG), Carsten Beta (UP)

MD simulations and multiscale modeling of specific membrane adhesion (project description)
PI: Thomas Weikl (MPIKG)
Collaboration: Emanuel Schneck (MPIKG)

Modeling molecular interactions of cellulose microfibrils (project description)
PI: Andrea Grafmüller (MPIKG)
Collaboration: Luca Bertinetti, John Dunlop (MPIKG)

Artificial organelle life: Compartmentalization of enzymatic reactions in lipid vesicles (project description)
PI: Tom Robinson (MPIKG)
Collaboration: Silke Leimkühler (UP)

GPI-anchored proteins attached to plasma membranes: molecular scale computer simulations (project description)
PI: Mark Santer (MPIKG)
Collaboration: Joachim Heberle (FU)

Life in micro-container (project description)
PI: Damien Faivre (MPIKG)
Collaboration: Tom Robinson (MPIKG)

Thermodynamics of interactions of polyanionic carbohydrates with bacteriophage proteins (project description)
PI: Stefanie Barbirz (UP)
Collaboration: Andrea Grafmüller (MPIKG)

Cooperative transport by amoeboid micro-trucks - a cellular tug-of-war (project description)
PI: Carsten Beta (UP)
Collaboration: Stefan Klumpp (UG), Reinhard Lipowsky (MPIKG)

Metal-coordinated self-healing peptide biomaterials (project description)
PI: Kerstin Blank (MPIKG)
Collaboration: Matt Harrington (MPIKG)

Light sensitive particles as a model of cellular motion (project description)
PI: Svetlana Santer (UP)
Collaboration: Mark Santer (MPIKG)
 

 

Blank.project.description.pdf — PDF document, 124 kB (127517 bytes)

Publications

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2017

 

Composition inversion to form calcium carbonate mixtures
Eddie Peh*, Clemens Liedel, Andreas Taubert, Klaus Tauer*
CrystEngComm, 2017, 19, 3573-3583

Proteolytic cleavage orchestrates cofactor insertion and protein assembly in [NiFe]-hydrogenase biosynthesis
Moritz Senger, Sven T. Stripp and Basem Soboh
The Journal of Biological Chemistry 292, 11670-11681 (2017).

Accumulating the hybride state in the catalytic cycle of [FeFe]-hydrogenases
Martin Winkler, Moritz Senger, Jifu Duan, Julian Esselborn, Florian Wittkamp, Eckhard Hofmann, Ulf-Peter Apfel, Sven Timo Stripp & Thomas Happe
Nature Communications 8, Article number: 16115 (2017)

The role of SufS is restricted to Fe-S cluster biosynthesis in Escherichia coli
Buehning, M; Valleriani, A..; Leimkuehler, S.
Biochemistry (2017) 56(14):1987-2000.

Photosensitive microgels containing azobenzene surfactants of different charge
Schimka, S.; Lomadze, N.; Rabe, M.; Kopyshev, A.; Lehmann, M.; von Klitzing, R.; Rumyantsev, A.M.; Kramarenko, E.; Santer, S.
Physical Chemistry Chemical Physics 19 (2017) 108-117

Molecular force sensors: From fundamental concepts toward applications in cell biology
Goktas, M.; Blank, K.G.
Advanced Materials Interfaces 4 (2017) 1600441

Electrocatalytic Z -> E isomerization of azobenzenes
Goulet-Hanssens, A., Utecht, M., Mutruc, D., Titov, E., Schwarz, J., Grubert, L., Bléger, D., Saalfrank, P.,  Hecht, S.
J. Am. Chem. Soc. 139 (2017) 335-341

Hierarchically Arranged Helical Fiber Actuators Derived from Commercial Cloth
J. Gong, H. Lin, J. W. C. Dunlop, J. Yuan*
Adv. Mater. 2017

Programmable actuation of porous poly(ionic liquid) membranes by aligned carbon nanotubes
H. Lin, J. Gong, M. Eder, R. Schuetz, H. Peng, J. Dunlop, J. Yuan
Adv. Mater. Interfaces 4 (2017) 1600768.

Connecting the sulfur mobilization routes for tRNA thiolation to molybdenum cofactor biosynthesis in prokaryotes and eukaryotes
Silke Leimkühler , Martin Bühning, Lena Beilschmidt
Biomolecules: tRNA Modification: Synthesis, Function and Beyond (2017)

2016

Borderline Particles: Approaching the Limit between Colloidal Stability and Instability during Heterophase Polymerization
Ran Yu, Eddie Peh, Liliia Mavliutova, Nancy Weber, Klaus Tauer
Macromol. Chem. Phys 2016, 217, 901-911 (DOI: 10.1002/macp.201500441)

Physical Gelation of α‑Helical Copolypeptides
Charlotte D. Vacogne, Michael Schopferer, Helmut Schlaad
Biomacromolecules, 2016, 17 (7), pp 2384–2391
http://pubsdc3.acs.org/doi/full/10.1021/acs.biomac.6b00427

Bacteriophage Tailspikes and Bacterial O-Antigens as a Model System to Study Weak-Affinity ProteinPolysaccharide Interactions
Yu Kang, Ulrich Gohlke, Olof Engstroem, Christoffer Hamark, Tom Scheidt, Sonja Kunstmann, Udo Heinemann, Goeran Widmalm, Mark Santer, Stefanie Barbirz
J. Am. Chem. Soc. (http://pubs.acs.org/doi/abs/10.1021/jacs.6b00240)

Photosensitive peptidomimetic for light controlled reversible DNA compaction
Selina Schimka, Svetlana A. Santer, Nina M. Mujkic-Ninnemann, David Bleger, Laura Hartmann, Marko Wehle, Reinhard Lipowsky, Mark Santer
Biomacromolecules (http://pubs.acs.org/doi/abs/10.1021/acs.biomac.6b00052)

From filter paper to functional actuator by Poly(Ionic Liquid)-modified graphene oxide
Haojie Song, Huijuan Lin, Markus Antonietti, Jiajin Yuan
Advanced Materials Interfaces, 1500743 (1-7), 2016

Nano-channels in the spiderfang for the transport of Zn ions to cross-link His-rich proteins pre-deposited in the cuticle matrix
Politi, Y., Pippel, E., Licuco-Massouh A.C.J.

Dynamics of azobenzene dimer photoisomerization: Electronic and steric effects
Titov, E., Granucci, G., Goetze, J.P., Persico, M., Saalfrank, P.
J. Phys. Chem. Lett. 7 (2016) 3591-3596

Excited states of xanthene analogues: Photofragmentation and calculations by CC2 and time-dependent density functional theory
A.J. Kulesza, E. Titov, S. Daly, R. Włodarczyk, J. Megow, P. Saalfrank, C.M. Choi, L. MacAleese, R. Antoine, P. Dugourd
ChemPhysChem 17 (2016) 3129-3138

Exciton splitting of adsorbed and free 4-nitroazobenzene dimers: A quantum chemical study
E. Titov, P. Saalfrank
J. Phys. Chem A 120 (2016) 3055-3070

Stepwise isotope editing of [FeFe]-hydrogenases exposes cofactor dynamics
Senger M, Mebs S, Duan J, Wittkamp F, Apfel UP, Heberle J, Haumann M, Stripp ST.
PNAS 113 (2016) 8454-8459

Complex carbohydrate recognition by proteins: Fundamental insights from bacteriophage cell adhesion systems
Broeker N.K., Andres D., Kang Y., Gohlke U., Schmidt A., Kunstmann S., Santer M., and Barbirz S
Perspectives in Science (2016)
 

2015
 

Contribution of MINCLE-SYC signaling to activation of primary human APCs by mycobacterial cord factor and the novel adjuvant TDB
Jenny Ostrop, Katrin Jozefowski, Stephanie Zimmermann, Katharina Hofmann, Erwin Strasser, Bernd Lepenies, Roland Lang
The Journal of Immunology 195, 2417-2428 (2015)

Presynaptic spinophilin tunes neurexin signalling to control active zone architecture and function
Karzan Muhammad, Suneel Reddy-Alla, Jan H Driller, Dietmar Schreiner, Ulises Rey, Mathias A. Böhme, Christina Hollmann, Niraja Ramesh, Harald Depner, Janine Lützkendorf, Tanja Matkovic, Torsten Götz, Dominique D. Bergeron, Jan Schmoranzer, Fabian Goettfert, Mathew Holt, Markus C. Wahl, Stefan W. Hell, Peter Scheiffele, Alexander M. Walter, Bernhard Loll & Stephan J. Sigrist
Nature Communications 6, 8362, doi:10.1038/ncomms9362

Primary Ammonium/Tertiary Amine-Mediated Controlled Ring Opening Polymerisation of Amino Acid N-Carboxyanhydrides
Vacogne, Charlotte D., Schlaad, Helmut
Chemical Communications, 51, 15645-15648 (2015)

A high affinity RIM-binding protein/Aplip1 interaction prevents the formation of ectopic axonal active zones
Matthias Siebert, Mathias A Böhme, Jan H Driller, Husam Babikir, Malou M Mampell, Ulises Rey, Niraja Ramesh, Tanja Matkovic, Nicole Holton, Suneel Reddy-Alla, Fabian Göttfert, Dirk Kamin, Christine Quentin, Susan Klinedinst, Till FM Andlauer, Stefan W Hell, Catherine A Collins, Markus C Wahl, Bernhard Loll, Stephan J Sigrist
eLife 2015;4:e06935

Shell Cleavable Dendritic Polyglycerol Sulfates Show High Anti-​Inflammatory Properties by Inhibiting L-​Selectin Binding and Complement Activation
Reimann, Sabine, Groeger, Dominic, Kuehne, Christian, Riese, Sebastian B., Dernedde, Jens, Haag, Rainer
Advanced Healthcare Materials 2015

Thermal Cis-to-Trans Isomerization of Azobenzene-Containing Molecules Enhanced by Gold Nanoparticles: An Experimental and Theoretical Study
Titov, Evgenii, Lysyakova, Liudmila, Lomadze, Nino, Kabashin, Andrei V., Saalfrank, Peter, Santer, Svetlana
The Journal of Physical Chemistry C 119, 17369-17377 (2015)

Fibrillar gels via the self-assembly of poly(L-glutamate)-based statistical copolymers
Vacogne, Charlotte D., Brosnan, Sarah M., Masic, Admir, Schlaad, Helmut
Polymer Chemistry 6, 5040-5052 (2015)

The C-Type Lectin Receptor Mincle Binds to Streptococcus pneumoniae but Plays a Limited Role in the Anti-Pneumococcal Innate Immune Response
Rabes, Anne, Zimmermann, Stephanie, Reppe, Katrin, Lang, Roland, Seeberger, Peter H., Suttorp, Norbert, Witzenrath, Martin, Lepenies, Bernd, Opitz, Bastian
PLOS ONE 10, e0117022 (2015)

Glycans as Vaccine Antigens and Adjuvants: Immunological Considerations.
Zimmermann, Stephanie, Lepenies, Bernd
Methods in Molecular Biology (Clifton, N.J.) 1331, 11-26 (2015)

Conformational and phase transitions in DNA–photosensitive surfactant solutions: Experiment and modeling
N. Kasyanenko, L. Lysyakova, R. Ramazanov, A. Nesterenko, I. Yaroshevich, E. Titov, G. Alexeev, A. Lezov, I. Unksov
Biopolymers 103 (2015) 109-122

2014

 

Differential Control of Mincle-Dependent Cord Factor Recognition and Macrophage Responses by the Transcription Factors C/EBP beta and HIF1 alpha
Schoenen, Hanne, Huber, Alexandra, Sonda, Nada, Zimmermann, Stephanie, Jantsch, Jonathan, Lepenies, Bernd, Bronte, Vincenzo, Lang, Roland
Journal of Immunology 193, 3664-3675 (2014)

A platform to screen for C-type lectin receptor-binding carbohydrates and their potential for cell-specific targeting and immune modulation
Maglinao, Maha, Eriksson, Magdalena, Schlegel, Mark K., Zimmermann, Stephanie, Johannssen, Timo, Goetze, Sebastian, Seeberger, Peter H., Lepenies, Bernd
Journal of Controlled Release 175, 36-42 (2014)

Diversity of Magneto-Aerotactic Behaviors and Oxygen Sensing Mechanisms in Cultured Magnetotactic Bacteria
Lefevre, Christopher T., Bennet, Mathieu, Landau, Livnat, Vach, Peter, Pignol, David, Bazylinski, Dennis A., Frankel, Richard B., Klumpp, Stefan, Faivre, Damien
Biophysical Journal 107, 527-538 (2014)

Phase diagrams of DNA-photosensitive surfactant complexes: Effect of ionic strength and surfactant structure
Zakrevskyy, Yuriy, Titov, Evgenii, Lomadze, Nino, Santer, Svetlana
Journal of Chemical Physics 141, 164904 (2014)

Selectivity in Bone Targeting with Multivalent Dendritic Polyanion Dye Conjugates
Groeger, Dominic, Kerschnitzki, Michael, Weinhart, Marie, Reimann, Sabine, Schneider, Tobias, Kohl, Benjamin, Wagermaier, Wolfgang, Schulze-Tanzil, Gundula, Fratzl, Peter, Haag, Rainer
Advanced Healthcare Materials 3, 375-385 (2014)

2013

 

The Sulfur Carrier Protein TusA Has a Pleiotropic Role in Escherichia coli That Also Affects Molybdenum Cofactor Biosynthesis
Dahl, Jan-Ulrik, Radon, Christin, Buehning, Martin, Nimtz, Manfred, Leichert, Lars I., Denis, Yann, Jourlin-Castelli, Cecile, Iobbi-Nivol, Chantal, Mejean, Vincent, Leimkuehler, Silke
Journal of Biological Chemistry 288, 5426-5442 (2013)

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